Mathematical modeling of biological systems based on the underlying mechanisms. The overarching theme of my projects is the use of a unified biological theory: the Dynamic Energy Budget (DEB) theory. My research interests include:
- Ecophysiology and investigation of the effect of stress factors (e.g. temperature, oxygen, toxicants, pathogens) on the metabolism of animal organisms.
- Physiology of phytoplankton, including the ecophysiology of mixotrophs and their impact on marine pelagic food webs
- Quantifying relationships between underlying processes of molecular/cellular mechanisms and bio-energetics at the individual level
- Aquaculture Applications: Developing modeling tools for designing experiments in aquaculture research facilities - Virtual laboratories
- AmP project
PUBLICATIONS
Journal articles
2024
2022
2021
2020
2019
2018
2017
2010-2015
2000-2009
1993-1999
- K. Lika, S.A.L.M. Kooijman. 2024. The metabolic interpretation of the von Bertalanffy growth rate. Ecological Modelling, 488: 110591. https://doi.org/10.1016/j.ecolmodel.2023.110591
- Firkus, T.J., Lika, K., Dean, N., Murphy, C.A.. 2023. The consequences of sea lamprey par-asitism on lake trout energy budgets. Conserv Physiol 11(1):coad006. doi: 10.1093/conphys/coad006.
- Stavrakidis-Zachou, O., Papandroulakis, N., Lika, K.. 2023. A bioenergetics approach to model-ling tolerance limits under acute thermal stress in farmed finfish. Frontiers Marine Sciences. 10:1173358. doi:10.3389/fmars.2023.1173358.
2022
- Stavrakidis-Zachou, O., Lika, K., Pavlidis, M., Mohamed, A.H. , Papandroulakis, N.. 2022. Met-abolic scope, performance and tolerance of juvenile European sea bass Dicentrarchus labrax upon acclimation to high temperatures. PLOS ONE 7(8):e0272510. doi:10.1371/journal.pone.0272510.
- Lika, K., Augustine, S., Kooijman, S.A.L.M.. 2022. The comparative energetics of the ray-finned fish in an evolutionary context. Conserv Physiol 10(1):coac039. doi:10.1093/conphys/coac039.
- Augustine, S., Lika, K., Kooijman, S.A.L.M.. 2022. The comparative energetics of the chon-drichthyans reveals universal links between respiration, reproduction and lifespan . J. Sea Res. 185:102228. doi: 10.1016/j.seares.2022.102228 .
- Marn, N., Lika, K., Augustine, S., Goussen, B., Ebeling, M., Heckmann, D., Gergs, A.. 2022. Energetic basis for bird ontogeny and egg-laying applied to the bobwhite quail. Conserv Physiol 10(1): coac063. doi:10.1093/conphys/coac063.
2021
- Stavrakidis-Zachou, O., Lika, K., P. Anastasiadis, N. Papandroulakis. 2021. Projecting climate change impacts on Mediterranean finfish production: A case study in Greece. Climatic Change 165:67, doi:10.1007/s10584-021-03096-y.
- Stavrakidis-Zachou, O., A. Sturm, Lika, K., Frank Wätzold N. Papandroulakis. 2021. ClimeGreAq: A software-based DSS for the climate change adaptation of Greek aquaculture. Environmental Modelling and Software. 143:105121, doi:10.1016/j.envsoft.2021.105121 .
- Livanou, E., Oikonomou, A., Psarra, S. Lika, K.. 2021. The role of mixotrophic nanoflagellates in the Eastern Mediterranean microbial food web. Marine Ecology Progress Series. 672:15-32. doi:10.3354/meps13782.
- Stavrakidis-Zachou, O., Lika, K., A. Tsalafouta, M. Pavlidis, A.H. Mohamed, N. Papan-droulakis 2021. Thermal tolerance, metabolic scope and performance of meagre, Argyrosomus regius, reared under high water temperatures, Journal of Thermal Biology. 100:103063. doi:10.1016/j.jtherbio.2021.103063.
- Kooijman, S.A.L.M., Lika, K., Augustine, S., Marn, N.. 2021. Multidimensional scaling for animal traits in the context of dynamic energy budget theory. Conserv Physiol 9(1): coab086. doi:10.1093/conphys/coab086.
2020
- Kooijman, S.A.L.M., Lika, K., Augustine, S., Marn, N., Kooi, B.W.. 2020. The Energetic basis of population growth in animal Kingdom. Ecological Modelling, doi: 10.1016/j.ecolmodel.2020.109055.
- Livanou, E., Barsakis, K., Psarra, S., Lika, K.. 2020. Modelling the nutritional strategies in mixotrophic nanoflagellates. Ecological Modelling, doi: 10.1016/j.ecolmodel.2020.109053.
- Lika, K., Augustine, S., Kooijman, S.A.L.M.. 2020. The use of augmented loss functions for estimating Dynamic Energy Budget parameters. Ecological Modelling, doi: 10.1016/j.ecolmodel.2020.109110.
- Augustine, S. ., Lika, K., Kooijman, S.A.L.M.. 2020. Comparing lossfunctions and interval estimates for survival data. Ecological Modelling, doi:10.1016/j.ecolmodel.2020.109077.
2019
- Augustine, S., Lika, K., Kooijman, S.A.L.M. 2019. Altricial-precocial spectra in animal kingdom. Journal of Sea Research, 143, 27-34. doi: 10.1016/j.seares.2018.03.006.
- Augustine, S., Lika, K., Kooijman, S.A.L.M. 2019. Why big-bodied animal species cannot evolve a waste-to-hurry strategy. Journal of Sea Research, 143, 18-26. doi: 10.1016/j.seares.2018.06.002.
- Lika, K., Augustine, S., Kooijman, S.A.L.M. 2019. Body size as emergent property of metabolism. Journal of Sea Research, 143, 8-17. doi: 10.1016/j.seares.2018.04.005.
- Livanou, E., Lagaria, A., Psarra, S., Lika, K. 2019. A DEB-based approach of modeling dissolved organic matter release by phytoplankton. Journal of Sea Research, 143, 140-151 doi: 10.1016/j.seares.2018.07.016.
- Livanou, E., Lagaria, A., Santi, I., Mandalakis, M., Pavlidou, A., Lika, K., Psarra, S. 2019. Pigmented and heterotrophic nanoflagellates: Abundance and grazing on prokaryotic picoplankton in the ultra-oligotrophic Eastern Mediterranean Sea. Deep-Sea Research Part II, 164, 100-111. doi: 10.1016/j.dsr2.2019.04.007.
- Marques, C.M., Lika, K., Augustine, S., Pecquerie, L., Kooijman, S.A.L.M. 2019. Fitting Multiple Models to Multiple Data Sets. Journal of Sea Research, 143, 48-56. doi: 10.1016/j.seares.2018.07.0048.
- Muller, E., Lika, K., Nisbet, R. Schultz, I., Casas, J., Gergs, A., Murphy, C., Nacci, D., Watanabe, K. 2019. Regulation of Reproductive Processes with Dynamic Energy Budgets. Functional Ecology, doi: 10.1111/1365-2435.13298.
- Stavrakidis-Zachou, O., Papandroulakis, N., Lika, K. 2019. A DEB model for European sea bass (Dicentrarchus labrax): parameterisation and application in aquaculture. Journal of Sea Research, 143, 262-271. Full text. doi: 10.1016/j.seares.2018.05.008.
- Stavrakidis-Zachou, O., Papandroulakis, N., Sturm, A., Anastasiadis, P., Watzold, F., Lika, K. 2019. Towards a computer-based Decision Support System for aquaculture stakeholders in Greece in the context of climate change. International Journal of Sustainable Agricultural Management and Informatics, doi: 10.1504/IJSAMI.2018.099235.
2018
- Marques, C.M., Augustine, S., Lika, K., Pecquerie, L., Kooijman, S.A.L.M. 2018. The AmP project: Comparing Species on the Basis of Dynamic Energy Budget Parameters. PloS Computational Biology, doi: doi.org/10.1371/journal.pcbi.1006100.
- Murphy, C.A., Nisbet, R.M., Antczak, P., Garcia-Reyero, N., Gergs, A., Lika, K., Mathews, T., Muller, E.B., Nacci, D., Peace, A., Remien, C.H., Schultz, I.R., Stevenson, L.M., Watanabe,K.H. 2018. Incorporating sub-organismal processes into dynamic energy budget models for ecological risk assessment. Integrated Environmental Assessment and Management, 14: 615-624. doi: doi.org/10.1002/ieam.4063.
- Samaras, A., Papandroulakis, N., Lika, K., Pavlidis, M. 2018. Water temperature modifies the acute stress response of European sea bass, Dicentrarchus labrax L. (1758). Journal of Thermal Biology 78:84-91 doi: 10.1016/j.jtherbio.2018.09.006.
2017
- Augustine, S., Lika, K., Kooijman, S.A.L.M. 2017. Comment on the ecophysiology of the Greenland shark, Somniosus microcephalus. Polar Biology, 40, 2429-2433. doi: 10.1007/s00300-017-2154-8.
- Pecquerie, L. and Lika, K.. 2017. Is reproduction limiting growth? Comment on ``Physics of metabolic organization'' by Marko Jusup et al. Phys Life Rev., 20:75-77. doi: 10.1016/j.plrev.2017.01.026.
2010-2015
- Samaras, A., Pavlidis, M. Lika, K., Theodoridi, A. and Papandroulakis, N. 2015. Scale matters: performance of European sea bass, Dicentrarchus labrax, L. (1758), reared in cages of different volumes. Aquaculture Research, 1-16, 10.1111/are.12942.
- Lika, K., Augustine, S., Pecquerie, L. and Kooijman, S.A.L.M. 2014. The bijection from data to parameter space with the standard deb model quantifies the supply-demand spectrum. Journal of Theoretical Biology, 354: 35-47 Abstract. doi: 10.1016/j.jtbi.2014.03.025.
- Lika, K., Kooijman, S.A.L.M. and Papandroulakis, N.. 2014. Metabolic acceleration in mediterranean perciformes. Journal of Sea Research, 94:37-46. . Abstract. doi: 10.1016/j.seares.2013.12.012.
- Lika, K., Pavlidis, M., Mitrizakis, N., Samaras A. and N. Papandroulakis, N. 2014. Do experimental units of different scale affect the biological performance of European sea bass larvae (Dicentrarchus labrax)? Journal of Fish Biology, 86:1271-1285 Abstract.
- Kooijman, S.A.L.M. and Lika, K.. 2014. Comparative energetics of the 5 fish classes on the basis of dynamic energy budgets. Journal of Sea Research, 94: 19-28.. Abstract. doi: 10.1016/j.seares.2014.01.015.
- Kooijman, S.A.L.M. and Lika, K.. 2014. Resource allocation to reproduction in animals. Biological Review, 89: 849-859. Abstract. doi: 10.1111/brv.12082.
- Rinaldi, A., Montalto, V., Lika, K., Sanfilippo, K., Manganaro, M. and Sara, G. 2014. Estimation of dynamic energy budget parameters for the mediterranean tootcarp (Aphanius fasciatus). Journal of Sea Research, 94: 65-70 Abstract. doi: 10.1016/j.seares.2014.05.006.
- Papandroulakis, N., Lika, K. , Kristiansen, T.S., Oppedal, F., Divanach, P. and Pavlidis, M.. 2013. Behaviour of European sea bass, Dicentrarchus labrax L., in cages - impact of early life rearing conditions and management. Aquaculture Research, 45: 1545-1558. Abstract. doi: 10.1111/are.12103.
- Papadakis, I.A., Kotzabasis, K. and Lika, K. . 2012. Modeling the dynamic modulation of light energy in photosynthetic algae. Journal of Theoretical Biology, 300:254-264. Abstract. doi: 10.1016/j.jtbi.2012.01.040
- Freitas, V., Lika, K. , Witte, J. IJ., Veer, H. W. v. d.. 2011. Food conditions of the sand goby Pomatoschistus minutus in shallow waters: an analysis in the context of Dynamic Energy Budget theory. Journal of Sea Research, 66:440-446. Abstract. doi: 10.1016/j.seares.2011.05.008
- Lika, K. and Kooijman, S.A.L.M.. 2011. The comparative topology of energy allocation in budget models. Journal of Sea Research, 66:281-291. Abstract. doi: 10.1016/j.seares.2011.10.005
- Lika, K. , Kearney, M. R., Freitas, V., Veer, H. W. v. d., Meer, J. v. d., Wijsman, J. W. M., Pecquerie, L., and Kooijman, S. A. L. M.. 2011. The `covariation method' for estimating the parameters of the standard Dynamic Energy Budget model I: philosophy and approach. Journal of Sea Research, 66:270-277. Abstract. doi: 10.1016/j.seares.2011.07.010
- Lika, K. , Kearney, M. R. and Kooijman, S.A.L.M.. 2011. The `covariation method' for estimating the parameters of the standard Dynamic Energy Budget model II: properties and preliminary patterns. Journal of Sea Research, 66:278-288. Abstract.doi: 10.1016/j.seares.2011.09.004
- Palialexis, A., Georgakarakos, S., Karakassis, I., Lika, K. and Valavanis, V. D.. 2011. Fish distribution predictions from different points of view: comparing associative neural networks, geostatistics and regression models. Hydrobiologia, 670:165-188. Abstract.doi: 10.1007/s10750-011-0676-6.
- Palialexis, A., Georgakarakos, S., Karakassis, I., Lika, K. and Valavanis, V. D.. 2011. Prediction of marine species distribution from presence-absence acoustic data: comparing the fitting efficiency and the predictive capacity of conventional and novel distribution models. Hydrobiologia, 670:241-266. Abstract.doi: 10.1007/s10750-011-0673-9
- Freitas, V., Cardoso, J.F.M.F., Lika, K. , Peck, M. A., Campos, J., Kooijman, S.A.L.M. and Veer, H. W. v. d., 2010, Temperature tolerance and energetics: a Dynamic Energy Budget-based comparison of North Atlantic marine species. Philosophical Transactions of the Royal Society B, 365: 3553-3565. Abstract. doi: 10.1098/rstb.2010.0049
2000-2009
- Lika, K. , and I. A. Papadakis, 2009, Modeling the biodegradation of phenolic compounds by microalgae. Journal of Sea Research, 62: 135-146. Abstract. doi: 10.1016/j.seares.2009.02.005.
- Triantis, K.A., Vardinogiannis, K., Tsolaki, E., Botsaris, I., Lika, K. and Mylonas, M.. 2006. Re-approaching small island effect. Journal of Biogeography, 33(5): 91-923. Abstract. doi: 10.1111/j.1365-2699.2006.01464.x.
- Triantis, K.A., Mylonas, M., Lika, K. and K. Vardinogiannis. 2005. Species richness, habitat diversity and area: A case study based on land snails in Skyros archipelago (Aegean Sea, Greece). Journal of Biogeography, 32: 1727-1735. Abstract. doi: 10.1111/j.1365-2699.2005.01322.x.
- Papadakis, I.A., Kotzabasis, K. and Lika, K. . 2005. A cell-based model for the photo- and CO2 - acclimation of the photosynthetic apparatus. Biochimica et Biophysica Acta- Bioenergetics, 1708: 250-261. Abstract. doi: 10.1016/j.bbabio.2005.03.001.
- Lika, K. and N. Papandroulakis. 2005. Modeling feeding processes: a test of a new model for sea bream (Sparus aurata L.) larvae. Canadian Journal of Fisheries and Aquatic Sciences, 62: 425-435. Abstract. doi: 10.1139/F04-198.
- Lika, K. and Kooijman, S.A.L.M.. 2003. Life history implications of allocation to growth versus reproduction in Dynamic Energy Budgets. Bulletin of Mathematical Biology, 5: 809-834. Abstract. doi: 10.1016/S0092-8240(03)00039-9.
- Triantis, K.A., Mylonas, M., Lika, K. and Vardinogiannis, K.. 2003. A model for species-area-habitat relationship. Journal of Biogeography, 30: 19-27. Abstract.
- Nisbet, R.M., Muller, E.B., Lika, K. and Kooijman, S.A.L.M.. 2000. From molecules to ecosystem through dynamic energy budget models. Journal of Animal Ecology, 69: 913-926. Abstract.
- Lika, K. and Nisbet, R.M.. 2000. A Dynamic Energy Budget Model based on Partitioning of Net Production. Journal of Mathematical Biology, 41: 361-386. Abstract.
1993-1999
- Lika, K. and Hallam, T.G.. 1999. Traveling Wave Solutions of a Nonlinear Reaction-Advection Equation. Journal of Mathematical Biology, 38: : 346-358. Abstract.
- Lika, K. and Hallam, T.G.. 1997. Modeling the Effects of Toxicants on a Fish Population in a Spatially Heterogeneous Environment: II. Lethal Effects. Nonlinear Analysis, Theory, Methods & Applications, 30:(3): 1709-1719. Abstract.
- Hallam, T.G. and Lika, K. . 1997. Modeling the Effects of Toxicants on a Fish Population in a Spatially Heterogeneous Environment: I. Behavior of the Unstressed, Spatial Model. Nonlinear Analysis, Theory, Methods & Applications, 30(3): 1699-1707. Abstract.
- Hallam, T.G., Funasaki, E.T., Lika, K. and Lee, H.L.. 1997. Utilities and Indicators of Stress Dynamics in Physiologically Structured Population Models. Environmental Modeling and Assessment, 2: 1-6. Abstract.
- Hallam, T.G., Canziani, G.A., and Lika, K. . 1996. On the Relationships Between Bioassays and Dynamics in Chemically Stressed, Aquatic Population Models. Ecologia Austral, 6: 45-54. Abstract.
- DeAngelis, D.L., Rose, K.A., Crowder, L.B., Marschall, E.A. and Lika, D. 1993. Fish Cohort Dynamics: Application of Complementary Modeling Approaches. The American Naturalist, 142 (4): 604-622. Abstract.
Book chapters
- C.A. Murphy, R.M. Nisbet, P. Antczak, N. Garcia-Reyero, A. Gergs, K. Lika, T. Mathews, E.B. Muller, D. Nacci, A. Peace, C.H. Remien, I.R. Schultz, K.H. Watanabe. 2017. Linking Adverse Outcome Pathways to Dynamic Energy Budgets: A conceptual model, In N. Garcia-Reyero and C.A. Murphy (eds) A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment. Springer, 401 pp. doi: 10.1007/978-3-319-66084-4_14.
- J. Val, F. Villa, K. Lika, and C. Boe. 1997. Nonlinear Models of Structured Populations: Dynamic Consequences of Stage Structure and Discrete Sampling Compared. In Structured Population Models in Marine, Freshwater, and Terrestrial Systems by S. Tuljapurkar and H. Caswell (eds). Chapman & Hall, pp. 587-613.